Cytostatic therapy for AA amyloidosis complicating psoriatic spondyloarthropathy

Cytostatic therapy for AA amyloidosis complicating psoriatic spondyloarthropathy.

Psoriatic spondyloarthropathy (PSA) can occasionally be complicated by AA amyloid, and renal amyloidosis should be suspected in patients with PSA who have unexplained proteinuria. The diagnosis of amyloidosis can be made either histologically or by radiolabelled serum amyloid P component (SAP) scintigraphy. Prognosis is determined by the extent of organ involvement and associated impairment of ...

Gastrointestinal amyloidosis complicating psoriatic arthropathy.

A patient is described who developed gastrointestinal amyloidosis complicating psoriatic arthropathy. The presenting symptom was progressive dysphagia due to oesophageal involvement. Other clinical features included gastric ulceration with melaena, intestinal pseudo-obstruction and evidence of impaired renal function. The oesophageal symptoms improved after endoscopic dilatation of the cardia. ...

Anti-Cytokine Therapy for AA Amyloidosis

Psoriatic spondyloarthropathy: a long term prospective study.

Fifty two patients with psoriatic spondyloarthropathy were monitored prospectively over a mean of 57 months (range 30-107). A comprehensive protocol was used to assess clinical and radiological features of disease activity and severity. Serial radiographs showed a significant increase in the number of patients with syndesmophyte formation and sacroiliitis. In contrast, there was no significant ...

Tocilizumab for the Treatment of AA Amyloidosis